CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| CALGB-40502 | CALGB | A Randomized Phase III Trial of Weekly Paclitaxel Compared to Weekly Nanoparticle Albumin Bound Nab-Paclitaxel or Ixabepilone With or Without Bevacizumab as First-Line Therapy for Locally Recurrent or Metastatic Breast Cancer<br> | Adult CIRB - Late Phase Emphasis | Available to Open |
| A171601 | Alliance | A phase II trial assessing the tolerability of palbociclib in combination with letrozole or fulvestrant in patients aged 70 and older with estrogen receptor-positive, HER2-negative metastatic breast cancer | Cancer Prevention and Control CIRB | Available to Open |
| ADVL1622 | COG | Phase 2 Trial of XL184 (Cabozantinib); an Oral Small-Molecule Inhibitor of Multiple Kinases; in Children and Young Adults with Refractory Sarcomas; Wilms Tumor; and Other Rare Tumors | Pediatric CIRB | Available to Open |
| MAY2015-05-01 | CLO-Mayo Clinic | Randomized, double-blind, placebo-controlled trial of Meriva® (curcuminoids) as a candidate chemoprevention agent for gastric carcinogenesis | Cancer Prevention and Control CIRB | Available to Open |
| EA6191 | ECOG-ACRIN | The BAMM2 (BRAF, Autophagy, MEK inhibition in Melanoma) Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib with or without Hydroxychloroquine in Advanced BRAF V600E/K Melanoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10405 | ETCTN | Phase I Trial of BAY 1895344 ATR Inhibitor Combined with Stereotactic Body Radiation Therapy and Pembrolizumab for Recurrent Head and Neck Squamous Cell Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| A011401 | Alliance | Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| EAQ171CD | ECOG-ACRIN | Implementing a Virtual Tobacco Treatment in Community Oncology Practices: “Smoke Free Support Study 2.0” | Cancer Prevention and Control CIRB | Available to Open |
| PBTC-056 | PBTC | A Phase I study of the ADAM-10 inhibitor, INCB7839 in children with recurrent/progressive high-grade gliomas to target microenvironmental neuroligin-3 | Pediatric CIRB | Available to Open |
| 10186 | ETCTN | A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma | Adult CIRB - Early Phase Emphasis | Available to Open |