CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| AEWS1221 | COG | Randomized Phase 3 Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479; NSC# 750008; IND# 120449) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma | Pediatric CIRB | Available to Open |
| ACCL1033 | COG | A Comprehensive Approach to Improve Medication Adherence in Pediatric ALL: A Group-wide Non-Therapeutic Study | Pediatric CIRB | Available to Open |
| PED-CITN-01 | Pediatric CITN | 3CI Study: Childhood Cancer Combination Immunotherapy. Phase 1b and Expansion Study of Nivolumab Combination Immunotherapy in Children, Adolescent and Young Adult (CAYA) Patients with Relapsed/Refractory Hypermutant Cancers | Pediatric CIRB | Completed |
| ANBL0421 | COG | A Phase II Study of Irinotecan + Temozolomide in Children with Recurrent Neuroblastoma: A Groupwide Phase II Study | Pediatric CIRB | Completed |
| ARST0431 | COG | Intensive Multi-Agent Therapy; Including Dose-Compressed Cycles of Ifosfamide/Etoposide (IE) and Vincristine/Doxorubicin/Cyclophosphamide (VDC) for Patients with High-Risk Rhabdomyosarcoma: A Groupwide Phase III Study | Pediatric CIRB | Completed |
| AAML1421 | COG | A Phase 1/2 Study of CPX-351 (NSC# 775341; IND #129443) Alone Followed by Fludarabine; Cytarabine; and G-CSF (FLAG) for Children with Relapsed Acute Myeloid Leukemia (AML) | Pediatric CIRB | Available to Open |
| ADVL0921 | COG | A Phase II Study of MLN8237 (IND# 102984); a Selective Aurora A Kinase Inhibitor in Children with Recurrent/Refractory Solid Tumors and Leukemias | Pediatric CIRB | Completed |
| ADVL1823 | COG | Larotrectinib (LOXO-101, NSC# 788607, IND# 141824) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias | Pediatric CIRB | Available to Open |
| SCUSF-0901 | COG | SCUSF 0901 [ACCL0922] A Phase II Placebo-Controlled Trial of Modafinil to Improve Neurocognitive Deficits in Children Treated for a Primary Brain Tumor | Pediatric CIRB | Available to Open |
| ALTE03N1 | COG | Key Adverse Events after Childhood Cancer | Pediatric CIRB | Available to Open |