CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10216 | ETCTN | A Phase I/II Study of AZD9291 (Osimertinib) and CB-839 HCl in Patients with EGFR Mutant Non-Small Cell Lung Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| S1905 | SWOG | A Phase I/II Study of AKR1C3-Activated Prodrug OBI‐3424 (OBI-3424) in Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL) | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10221 | ETCTN | A Phase I/II Biomarker Driven Combination Trial of Copanlisib and Immune Checkpoint Inhibitors in patients with advanced solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10324 | ETCTN | A Phase I/Ib Dose Escalation Study of Pegylated Liposomal Doxorubicin (PLD) With M3814 in Platinum-Resistant or Ineligible Ovarian and Related Cancers with Planned Expansions in High Grade Serous (HGSOC) and Low Grade Serous Ovarian Cancer (LGSOC) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10388 | ETCTN | A Phase I Trial of Triapine and Lutetium Lu 177 Dotatate in Combination for Well-Differentiated Somatostatin Receptor-Positive Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) | Adult CIRB - Early Phase Emphasis | Available to Open |
| UWI2014-03-01 | CP-CTNet_CLO-University of Wisconsin | A Phase I Trial of the Safety and Immunogenicity of a DNA Plasmid Based Vaccine (WOKVAC) Encoding Epitopes Derived from Three Breast Cancer Antigens (IGFBP-2, HER2, AND IGF-1R) in Patients with Breast Cancer | Cancer Prevention and Control CIRB | Available to Open |
| 9924 | ETCTN | A Phase I Trial of the Combination of Lenalidomide and Blinatumomab in Patients with Relapsed or Refractory Non-Hodgkins Lymphoma (NHL) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9930 | ETCTN | A Phase I Trial of MEDI-570 in Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma (PTCL) Follicular Variant and Angioimmunoblastic T-Cell Lymphoma (AITL) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9898 | ETCTN | A Phase I Trial of AZD9291 and Necitumumab in EGFR-Mutant Non-Small Cell Lung Cancer After Progression on a Previous EGFR Tyrosine Kinase Inhibitor | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9874 | ETCTN | A Phase I Trial of AT13387 in Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (LA-SCCHN) receiving Concurrent Radiation and Cisplatin | Adult CIRB - Early Phase Emphasis | Completed |