CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| EA9181 | ECOG-ACRIN | A Phase III Randomized Trial of Steroids +Tyrosine Kinase Inhibitor Induction with Chemotherapy or Blinatumomab for Newly Diagnosed BCR-ABL-positive Acute Lymphoblastic Leukemia in Adults | Adult CIRB - Late Phase Emphasis | Available to Open |
| ACOSOG-Z1031 | ACSOG | A Randomized Phase III Trial Comparing 16 to 18 Weeks of Neoadjuvant Exemestane (25 mg daily); Letrozole (2.5 mg); or Anastrozole (1 mg) in Postmenopausal Women with Clinical Stage II and III Estrogen Receptor Positive Breast Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| B-31 dbGAP | NSABP | Comparison of methods for development of predictive signatures for therapy selection | Adult CIRB - Late Phase Emphasis | Available to Open |
| RTOG-0436 | RTOG | A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel; Cisplatin; and Radiation for Patients with Esophageal Cancer who are Treated without Surgery | Adult CIRB - Late Phase Emphasis | Completed |
| S0337 | SWOG | A Phase III Blinded Study of Immediate Post-TURBT Instillation of Gemcitabine Versus Saline in Patients with Newly Diagnosed or Occasionally Recurring Grade I/II Superficial Bladder Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| A091404 | Alliance | A Phase II Study of Enzalutamide (NSC# 766085) for Patients with Androgen Receptor Positive Salivary Cancers | Adult CIRB - Late Phase Emphasis | Available to Open |
| GOG-0218 | GOG | A Phase III Trial of Carboplatin and Paclitaxel Plus Placebo Versus Carboplatin and Paclitaxel Plus Concurrent Bevacizumab (NSC #704865; IND #113912) Followed by Placebo; Versus Carboplatin and Paclitaxel Plus Concurrent and Extended Bevacizumab; in Women With Newly Diagnosed; Previously Untreated; Stage III or IV; Epithelial Ovarian; Primary Peritoneal or Fallopian Tube Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| A051902 | Alliance | A Randomized Phase II Study of CHO(E)P vs CC-486-CHO(E)P vs Duvelisib-CHO(E)P in Previously Untreated CD30 Negative Peripheral T-Cell Lymphomas | Adult CIRB - Late Phase Emphasis | Available to Open |
| E1105 | ECOG | A Randomized Phase III Double-Blind Placebo-Controlled Trial of First-line Chemotherapy and Trastuzumab with or without Bevacizumab for Patients with HER-2/NEU Over-expressing Metastatic Breast Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| LungMAP | SWOG | A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study) | Adult CIRB - Late Phase Emphasis | Available to Open |