CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| ACCL1633 | COG | The Effectiveness of Lactobacillus plantarum (LBP, IND #17339) In preventing Acute Graft-versus-Host Disease (GvHD) in Children undergoing Alternative Hematopoietic Progenitor Cell Transplantation (HCT) | Pediatric CIRB | Available to Open |
| ARST0921 | COG | A Randomized Phase II Trial of Bevacizumab (IND# 7921; Avastin) and Temsirolimus (IND# 61010; Torisel) in Combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/Refractory Rhabdomyosarcoma: A Groupwide Phase II Study | Pediatric CIRB | Completed |
| ACCL1034 | COG | Impact of Cleansing with Chlorhexidine Gluconate (CHG) on Reducing Central Line Associated Bloodstream Infection (CLABSI) and Acquisition of Multi-drug Resistant Organisms (MDRO) in Children with Cancer or Those Receiving Allogeneic Hematopoietic Cell Transplantation (HCT): A Limited Phase III Study | Pediatric CIRB | Completed |
| ADVL1514 | COG | A Phase 1 Study of ABI-009 (nab-Rapamycin) (IND# 133537) in Pediatric Patients with Recurrent or Refractory Solid Tumors, Including CNS Tumors as a Single Agent and in Combination with Temozolomide and Irinotecan | Pediatric CIRB | Available to Open |
| AGCT1532 | COG | Phase 3 Accelerated BEP Trial: A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumors | Pediatric CIRB | Available to Open |
| AAML06P1 | COG | A Pilot Study of Lestaurtinib (CEP-701) in Combination with Chemotherapy in Young Patients with Relapsed or Refractory FLT3-mutant Acute Myeloid Leukemia | Pediatric CIRB | Completed |
| ACNS1021 | COG | A Phase II Study of Sunitinib (NSC# 736511; IND# 74019) in Recurrent; Refractory or Progressive High Grade Glioma and Ependymoma Tumors in Pediatric and Young Adult Patients | Pediatric CIRB | Completed |
| ALTE21C1 | COG | Assessment of Clonal Hematopoiesis and its Relationship to Cardiovascular Disease in Hodgkin Lymphoma Survivors | Pediatric CIRB | Available to Open |
| ANBL1821 | COG | A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or without Eflornithine (DFMO) (IND# TBD) in Children with Relapsed, Refractory or Progressive Neuroblastoma | Pediatric CIRB | Available to Open |
| AHEP0731 | COG | Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND#122782; NSC#683864) Added to High Risk Stratum Treatment: A Groupwide Phase III Study | Pediatric CIRB | Available to Open |