CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10389 | ETCTN | A Phase 1 Trial Combining WEE1 Inhibitor Adavosertib (AZD1775) with Radiation Therapy for Metastatic or Inoperable and Ineligible for Definitive Chemoradiation Esophageal and Gastroesophageal Junction Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10388 | ETCTN | A Phase I Trial of Triapine and Lutetium Lu 177 Dotatate in Combination for Well-Differentiated Somatostatin Receptor-Positive Gastroenteropancreatic Neuroendocrine Tumors (GEP-NETs) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10387 | ETCTN | Pilot Trial of Nivolumab plus Cabozantinib for Advanced Solid Tumors in Patients with HIV infection | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10384 | ETCTN | A Phase 1b/2 Study of Hu5F9-G4 (magrolimab) in Combination with Mogamulizumab in Relapsed/Refractory Treated T- cell Lymphoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10382 | ETCTN | A Phase I/II Trial Evaluating the Safety and Efficacy of Eribulin in Combination with Copanlisib in Patients with Metastatic Triple Negative Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10371 | ETCTN | A Pharmacodynamics-Driven Trial of Talazoparib, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Aberrations in Genes Involved in DNA Damage Response | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10367 | ETCTN | A Phase 1b Study with Expansion Cohort of Escalating Doses of KRT-232 (AMG 232) Administered in Combination with Standard Induction Chemotherapy (Cytarabine and Idarubicin) in Newly Diagnosed Acute Myelogenous Leukemia (AML) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10366 | ETCTN | A Phase 1/2 Study of M3814 (peposertib) in Combination with Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10358 | ETCTN | Phase 1/1B study of DS-8201a in combination with ATR Inhibition (AZD6738) in advanced solid tumors with HER2 expression (DASH Trial) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10355 | ETCTN | A phase I study of DS-8201a in combination with olaparib in HER2-expressing malignancies | Adult CIRB - Early Phase Emphasis | Available to Open |