CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| S2213 | SWOG | A Phase III, Randomized Study of Daratumumab, Cyclophosphamide, Bortezomib and Dexamethasone (Dara-VCD) Induction Followed by Autologous Stem Cell Transplant or Dara-VCD Consolidation and Daratumumab Maintenance in Patients with Newly Diagnosed AL Amyloidosis | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10015 | ETCTN | A Non-Randomized; Open-Label; Phase 2 Study of Trametinib in Patients with Unresectable or Metastatic Epithelioid Hemangioendothelioma | Adult CIRB - Early Phase Emphasis | Available to Open |
| DCP-002 | NCI | Early Onset Malignancy Initiative (EOMI): Molecular Profiling of Breast; Prostate; Colorectal; Liver; Kidney; and Multiple Myeloma Among Racially and Ethnically Diverse Populations | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10315 | ETCTN | A Phase 2 Study of XL184 (Cabozantinib) in Combination with Nivolumab and Ipilimumab for the Treatment of Poorly Differentiated Neuroendocrine Carcinomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| PBTC-056 | PBTC | A Phase I study of the ADAM-10 inhibitor, INCB7839 in children with recurrent/progressive high-grade gliomas to target microenvironmental neuroligin-3 | Pediatric CIRB | Available to Open |
| EA9131 | ECOG-ACRIN | A Simplified Patient Care Strategy to Decrease Early Deaths in Acute Promyelocytic Leukemia (APL) | Cancer Prevention and Control CIRB | Available to Open |
| S1418 | SWOG | A Randomized; Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with >/=1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN+) after Neoadjuvant Chemotherapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA2197 | ECOG-ACRIN | Optimal Perioperative Therapy For Incidental Gallbladder Cancer (OPT-IN): A Randomized Phase II/III Trial | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-BR007 | NRG | A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score ≤18 Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| PEPN2111 | PEP-CTN | A Phase 1/2 Trial of CBL0137 (NSC# 825802, IND# TBD) in Patients with Relapsed or Refractory Solid Tumors including CNS Tumors and Lymphoma | Pediatric CIRB | Available to Open |