CIRB Studies

Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.

To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.

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Study Number Lead Group Study Title CIRB Study Status
PBTC-055 PBTC Phase I/II trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF fusion/duplication positive or NF1-associated recurrent or progressive gliomas in children and young adults Pediatric CIRB Available to Open
ABTC-1802 ABTC A Phase II Study of Binimetinib in Combination with Encorafenib in Adults with Recurrent BRAF V600-Mutated High-Grade Astrocytoma or other Primary Brain Tumor Adult CIRB - Late Phase Emphasis Available to Open
ABTC-1801 ABTC Phase I/II Study of Pamiparib (BGB-290) with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations Adult CIRB - Early Phase Emphasis Available to Open
ABTC-1701 ABTC Pilot Surgical PK Study of BGB324 in Recurrent Glioblastoma Patients Adult CIRB - Early Phase Emphasis Available to Open
ABTC-1804 ABTC Determining the Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients with Gliomas Adult CIRB - Late Phase Emphasis Available to Open
CITN-17 CITN Phase 1 Study of NT-I7 (rhIL-7-hyFc) for the Treatment of Kaposi Sarcoma in Patients With or Without Infection with HIV Adult CIRB - Early Phase Emphasis Available to Open
CITN-14 CITN A Randomized Phase II Study of Atezolizumab (MPDL3280A) plus Recombinant Human IL-7 (CYT107) in patients with locally advanced or metastatic urothelial carcinoma Adult CIRB - Early Phase Emphasis Available to Open
PED-CITN-02 Pediatric CITN GD2-CAR PERSIST: Production and Engineering of GD2-Targeted, Receptor Modified T Cells (GD2CART) for Sarcoma and Neuroblastoma to Increase Systemic Tumor Exposure Pediatric CIRB Available to Open
PED-CITN-01 Pediatric CITN 3CI Study: Childhood Cancer Combination Immunotherapy. Phase 1b and Expansion Study of Nivolumab Combination Immunotherapy in Children, Adolescent and Young Adult (CAYA) Patients with Relapsed/Refractory Hypermutant Cancers Pediatric CIRB Available to Open
PED-CITN-03 Pediatric CITN Phase 1 Trial of Hu5F9-G4 (Magrolimab) Combined with Dinutuximab in Children and Young Adults with Relapsed and Refractory Neuroblastoma or Relapsed Osteosarcoma Pediatric CIRB Available to Open
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