CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| AAML0431 | COG | The Treatment of Down Syndrome Children with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Under the Age of 4 Years: A Groupwide Phase III Study | Pediatric CIRB | Completed |
| APEC14B1 | COG | The Project: Everychild Protocol: A Registry; Eligibility Screening; Biology and Outcome Study | Pediatric CIRB | Available to Open |
| 10264 | ETCTN | The PRIME Trial: PARP Inhibition in IDH Mutant Effectiveness Trial. A Phase II Study of Olaparib in Isocitrate Dehydrogenase (IDH) Mutant Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-GU013 | NRG | The Phase III "High Five Trial" Five Fraction Radiation for High-Risk Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| CCTG-CO32 | CCTG | The NEO-RT Trial: A Phase 3 Randomized Trial of Neoadjuvant Chemotherapy, Excision and Observation versus ChemoRadioTherapy for Early Rectal Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NHLBI-MDS | ECOG | The National Myelodysplastic Syndromes (MDS) Study | Cancer Prevention and Control CIRB | Available to Open |
| A022104 | Alliance | The Janus Rectal Cancer Trial: A Randomized Phase II Trial Testing the Efficacy of Triplet versus Doublet Chemotherapy to Achieve Clinical Response in Patients with Locally Advanced Rectal Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NCIC-MA.27B | NCIC CTG | The Influence of Five Years of Adjuvant Anastrozole or Exemestane on bone Mineral Density in Postmenopausal Women with Primary Breast Cancer - A Companion Study to NCIC CTG MA.27 | Adult CIRB - Late Phase Emphasis | Completed |
| ACCL1633 | COG | The Effectiveness of Lactobacillus plantarum (LBP, IND #17339) In preventing Acute Graft-versus-Host Disease (GvHD) in Children undergoing Alternative Hematopoietic Progenitor Cell Transplantation (HCT) | Pediatric CIRB | Available to Open |
| A011801 | Alliance | The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): CompassHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 and Placebo Compared with T-DM1 and Tucatinb | Adult CIRB - Late Phase Emphasis | Available to Open |