CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| A051701 | Alliance | Randomized Phase II/III Study of Venetoclax (ABT 199) Plus Chemoimmunotherapy for MYC/BCL2 Double-Hit and Double-Expressing Lymphomas | Adult CIRB - Late Phase Emphasis | Available to Open |
| A041501 | Alliance | A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (A Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) with Newly Diagnosed Precursor B-Cell ALL | Adult CIRB - Late Phase Emphasis | Available to Open |
| A221405 | Alliance | A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women with Endocrine Responsive Breast Cancer who Desire Pregnancy | Cancer Prevention and Control CIRB | Available to Open |
| A061402 | Alliance | Solitary Plasmacytoma of Bone: Randomized Phase III Trial to Evaluate Treatment with Adjuvant Systemic Treatment and Zoledronic Acid Versus Zoledronic Acid After Definite Radiation Therapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A022106 | Alliance | Phase II/III Second-Line NABPLAGEM vs. Nab-Paclitaxel/Gemcitabine in BRCA1/2 or PALB2 Mutant Metastatic Pancreatic Ductal Adenocarcinoma (PLATINUM) | Adult CIRB - Late Phase Emphasis | Available to Open |
| A031801 | Alliance | A Phase II Randomized Trial of Radium-223 Dichloride and Cabozantinib in Patients with Advanced Renal Cell Carcinoma with Bone Metastasis (RADICAL) | Adult CIRB - Late Phase Emphasis | Available to Open |
| A191901 | Alliance | Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions | Cancer Prevention and Control CIRB | Available to Open |
| A082002 | Alliance | A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy with or without SBRT for PD-L1-Negative, Advanced Non-small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| A031701 | Alliance | A Phase II Study of Dose-Dense Gemcitabine Plus Cisplatin (DDGC) in Patients with Muscle-Invasive Bladder Cancer with Bladder Preservation for Those Patients Whose Tumors Harbor Deleterious DNA Damage Response (DDR) Gene Alterations | Adult CIRB - Late Phase Emphasis | Available to Open |
| A091304 | Alliance | A Phase I /Randomized Phase II Study of MLN0128 (TAK-228) vs. Pazopanib In Patients With Locally Advanced/Unresectable And/Or Metastatic Sarcoma | Adult CIRB - Early Phase Emphasis | Completed |