Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
|Study Number||Lead Group||Study Title||CIRB||Study Status|
|9952||ETCTN||Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of M6620 (VX‐970) When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Lung Cancer||Adult CIRB - Early Phase Emphasis||Available to Open|
|NRG-GY018||NRG||A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864) in Addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer||Adult CIRB - Late Phase Emphasis||Available to Open|
|10273||ETCTN||A Phase 1 Study of M3814 in combination with MEC in Patients with Relapsed or Refractory Acute Myeloid Leukemia||Adult CIRB - Early Phase Emphasis||Available to Open|
|10129||ETCTN||A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 mutant Advanced Solid Tumors||Adult CIRB - Early Phase Emphasis||Available to Open|
|TRC-10446||NCI||Tocilizumab in Hospitalized Cancer Patients with Coronavirus 2019 (SARS-CoV-2) and Severe Complications of Coronavirus Disease 19 (COVID-19)||Adult CIRB - Late Phase Emphasis||Available to Open|
|EA2161||ECOG-ACRIN||A Phase II Study of MLN0128 (TAK-228) in Rapalog-Resistant Advanced Pancreatic Neuroendocrine Tumors (PNET)||Adult CIRB - Late Phase Emphasis||Available to Open|
|A221405||Alliance||A Study Evaluating the Pregnancy Outcomes and Safety of Interrupting Endocrine Therapy for Young Women with Endocrine Responsive Breast Cancer who Desire Pregnancy||Cancer Prevention and Control CIRB||Available to Open|
|10445||ETCTN||Phase I Dose Escalation and Expansion Study of Tazemetostat in Combination with Topotecan and Pembrolizumab in Recurrent Small Cell Lung Cancer||Adult CIRB - Early Phase Emphasis||Available to Open|
|A031902||Alliance||CASPAR - A Phase III Trial of Enzalutamide and Rucaparib as a Novel Therapy in First-Line Metastatic Castration-Resistant Prostate Cancer||Adult CIRB - Late Phase Emphasis||Available to Open|
|NRG-CC005||NRG||FORTE (Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps)||Cancer Prevention and Control CIRB||Available to Open|