CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| AALL1731 | COG | A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy) | Pediatric CIRB | Available to Open |
| DCP-002 | NCI | Early Onset Malignancy Initiative (EOMI): Molecular Profiling of Breast; Prostate; Colorectal; Liver; Kidney; and Multiple Myeloma Among Racially and Ethnically Diverse Populations | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-GU008 | NRG | Randomized Phase III Trial Incorporating Abiraterone Acetate with Prednisone and Apalutamide and Advanced Imaging into Salvage Treatment for Patients with Node-Positive Prostate Cancer after Radical Prostatectomy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A091605 | Alliance | A Randomized Phase II Study of anti-PD1 antibody [MK-3475 (pembrolizumab)] alone versus anti- PD1 antibody plus Stereotactic Body Radiation therapy in advanced Merkel Cell Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| ANBL1232 | COG | Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma. A Groupwide Historically Controlled Phase III Study | Pediatric CIRB | Available to Open |
| AALL0331 | COG | Standard Risk B-precursor Acute Lymphoblastic Leukemia (ALL): A Phase III Group-Wide Study | Pediatric CIRB | Available to Open |
| A011203 | Alliance | A Randomized Phase II Trial of Tamoxifen Versus Z-Endoxifen HCL in Postmenopausal Women with Metastatic; Estrogen Receptor Positive; HER2 Negative Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-BN009 | NRG | Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse after Upfront SRS with Brain Metastasis Velocity ≥4 Brain Metastases/Year | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GY016 | NRG | A Phase II Study of MK-3475 (Pembrolizumab) (NSC #776864) + Epacadostat (NSC #766086) in Recurrent Clear Cell Carcinoma of the Ovary | Adult CIRB - Late Phase Emphasis | Available to Open |
| ADVL1614 | COG | A Phase 1/2 Study of VX15/2503 (IND #136181) in Children, Adolescents, or Young Adults with Recurrent or Relapsed Solid Tumors | Pediatric CIRB | Available to Open |